The Molecular Mechanisms Underlying Diabesity Group at the Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO) seeks for a candidate to apply for the Marie S.-Curie Individual Fellowships (H2020-MSCA-IF-2019) call.

Candidate requirements – The ones settled by the H2020-MSCA-IF-2019 call, https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/msca-if-2019. .

Ideal candidates – Researchers that comply with the requirements (please check before sending your application) and have a broad experience in oxidative stress, mitochondrial function and underlying molecular mechanisms involved in cardiometabolic diseases.

FISABIO is a non-profit scientific and healthcare entity, whose primary purpose is to encourage, to promote and to develop scientific and technical health and biomedical research in Valencia Region, Spain.

The main aim of the project proposed by the Molecular Mechanisms Underlying Diabesity Group is to determine how non-surgical periodontal treatment in patients with chronic periodontitis can affect leukocyte activation and the oral bacterial microbiome by performing an in-depth analysis of the molecular mechanisms associated with atherosclerosis. Concretely, using next-generation sequencing of the 16S rRNA gene of the microbiome of the subgingival plaque, we believe that, following non-surgical periodontal treatment, we will observe a shift in the bacterial community that will improve both classic and emerging cardiovascular risk parameters, subclinical markers of atherosclerosis and inflammation in patients with and without insulin resistance, as well as in women with polycystic ovary syndrome. Moreover, we will evaluate this relation with different oxidative stress markers, mitochondrial function, endoplasmic reticulum stress and endothelial function of leukocytes in peripheral blood (static cytometry, Clark electrode, Seahorse XFe24 Extracellular Flux Analyzer, Western Blot, RT-PCR and parallel-plate flow plate), and its systemic consequences by analysing inflammatory parameters and molecular adhesion (X-MAP technology, Luminex®). Finally, we will assess the effects of pinitol as an anti-inflammatory compound on peripheral mononuclear blood cells and HUVEC in order to determine its potential role in the improvement of leukocyte-endothelium interactions in patients with chronic periodontitis.

For this purpose, we are looking for researchers in biomedicine with broad experience in oxidative stress, mitochondrial function and underlying molecular mechanisms involved in cardiometabolic diseases.

Contact persons/Scientists in charge – Milagros Rocha <milagros.rocha@uv.es> / Víctor Manuel Víctor <victor.victor@uv.es>.

Documents to be submitted for the EoI - CV and cover letter.