13/06/2022

PhD Position in Functional and Structural Genomics

Dieses Jobangebot ist nicht mehr aktuell


  • ORGANISATION/EINRICHTUNG
    German Cancer Research Center in the Helmholtz Association (DKFZ)
  • FORSCHUNGSBEREICH
    Biological sciences
    Chemistry
  • KARRIERESTUFE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
  • BEWERBUNGSFRIST
    15/07/2022 23:59 - Europe/Brussels
  • STANDORT
    Germany › Heidelberg
  • KONTAKTTYP
    Other
  • JOB STATUS
    Full-time

OFFER DESCRIPTION

The German Cancer Re­search Center is the largest bio­medi­cal re­search insti­tu­tion in Germany. With more than 3,000 employees, we operate an exten­sive scien­tific program in the field of cancer research.

The Junior Research Group "Brain Tumor Translational Targets" is offering a

PhD Position in Functional and Structural Genomics
(Ref-No. 2022-0200)

Description:
The goal of the project is to develop a novel strategy for glioblastoma (GBM) therapy by harnessing the unique ability of an exosome nanosystem to overcome the blood brain barrier (BBB) and deliver malformin C, a small-molecule inhibitor which specifically targets and leads to death of glioblastoma stem-like cells (GSCs).

GBM, the most common and aggressive primary brain tumor type in adults, is highly resistant to treatment, and has a median survival of ~15 months. This grim prognosis is largely due to two key factors: The BBB, a formidable barrier to brain delivery of drugs, including small molecules; and a sub-population of GBM stem-like cells, GSCs, which are emerging as being responsible for resistance to chemotherapy and radiotherapy. These non-specific treatments, together with a lack of known tumor-specific targets for GSCs, prevents selective eradication of malignant cells, and moreover, leads to severe adverse effects on healthy tissue. Thus, it is of utmost importance to discover new compounds that can reach the tumor and target GSCs to serve as next-generation cancer drugs.

In that respect, we will develop an innovative theranostic exosome drug-nanosystem which crosses the BBB, homes in to the tumor, and delivers malformin C. Malformin C delivered by the exosomes will specifically target GSCs and inhibit tumor growth, whilst sparing healthy cells. Real-time CT tracking of the exosomes with the gold particles will provide unprecedented data regarding biodistribution (BD), pharmacokinetics (PK) and treatment efficacy, and will also enable prediction of response to treatment at an early timepoint based on image-guided analysis of tumor accumulation.

Your profile:
The project requires a master's degree in biology or in a related field with practical experience in a research laboratory. Previous work in cell culture and molecular biology techniques, as well as willingness to work with mouse models are essential. Experience in chemistry and stem cell culture is preferable. Excellent verbal and written communication skills (English) and the ability to work both independently and in a team environment are required.

We offer:
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School

The position is limited to 3 years.

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.

For further information please contact
Dr. Violaine Rosenstiel-Goidts, phone +49(0)6221/42-4635.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebs­forschungs­zentrum, Personal­abteilung, Im Neuen­heimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apolo­gize for any inconvenience this may cause.

Mehr Information

Anforderungen für das Jobangebot

Kenntnisse/Qualifikationen

Masters

Arbeitsort
1 position(s) available at
German Cancer Research Center in the Helmholtz Association (DKFZ)
Germany
Heidelberg

EURAXESS Angebots-ID: 798857
Angebots-ID der veröffentlichenden Einrichtung: 759691

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