03/07/2020
Science 4 Refugees

Postdoc - HT Screening on Therapeutic Target for Poly-Glutamine Diseases (f/m/d)

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  • ORGANISATION/EINRICHTUNG
    Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
  • FORSCHUNGSBEREICH
    Medical sciences
  • KARRIERESTUFE
    Recognised Researcher (R2)
    Established Researcher (R3)
  • BEWERBUNGSFRIST
    31/07/2020 00:00 - Europe/Brussels
  • STANDORT
    Germany › Neuherberg (bei München)
  • KONTAKTTYP
    To be defined
  • JOB STATUS
    Other

Work group:

Institute of Structural Biology

Area of research:

Scientific / postdoctoral posts

Starting date:

01.10.2020

Contract time limit:

31.05.2022

Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

News on the Corona pandemic: We continue to recruit and are looking exactly for you. To this end, we have adapted our recruitment process to ensure the greatest possible health protection for both our applicants and our employees. After successfully reviewing your application documents, we will invite you to a friendly video call or telephone interview, no special devices needed. Here we simulate a face-to-face interview situation in order to get to know you better. Fight with us against the spread of environmentally related diseases and apply now.

The Niessing lab at the Institute of Structural Biology offers a stimulating international environment. Our spectrum of expertise ranges from X-ray crystallography, biochemistry and quantitative biophysics to (stem) cell research and high-throughput screening.

We are looking for a highly motivated

Postdoc - HT Screening on Therapeutic Target for Poly-Glutamine Diseases (f/m/d)
2020/0141

Your mission

Poly-glutamine disorders, such as Huntingtons disease, are caused by poly-glutamine expansions and results in progressive neurodegeneration and ultimately in the death of patients. Although no established treatment is available to cure the disease, clinical trials are underway to achieve this goal. 

The project builds on a well established collaboration with researchers at the RWTH Aachen, which have identified a methyltransferase as novel drug target against poly-glutamin diseases. Together, we recently received funding via the BMBF call "target validation" to perform a high-throughput screening campaign to identify inhibitors of this enzyme. Towards this goal, we have already finished a number of pilot studies. Performing the screen will be a central aspect of the announced position and will be done with support and in close collaboration with other groups of the Chemical Biology Initiative of the Helmholtz Zentrum München.

Cell-based models and model organisms are available to complement the screening campaign. These additional tools will be important to validate and further improve initial hits from the screen.

Your Qualification

You are an independent creative thinker driven by curiosityPhD degree in biology, biochemistry, biotechnology or equivalentExpertise in recombinant protein expressionIdeally, skills in enzymatic assays Expertise/strong interest in high-throughput screening campaignsProficient in written and spoken EnglishExperience in international interdisciplinary research teams

We are explicitly looking for team workers.

What we offer you

A challenging and versatile field of work providing you with the freedom to follow your instinct and be creative. With the help of extensive and goal-orientated professional development measures and career-building programmes we encourage you to grow as a person. To ensure a good work/life balance we assist you with flexible working hours, in-house health management, a nursery, and an “Elder Care” concept as well as other consultation and support options.

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and research institutes it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund).

The position is (initially) limited, but under certain circumstances an extension can be arranged.

As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.

Curious? If you have further questions, simply contact Prof.Dr. Dierk Niessing on niessing@helmholtz-muenchen.de.

We are looking forward to receiving your comprehensive online application until July 31st 2020.

Karteninformation

Arbeitsort Orte für persönliche Beratung
Arbeitsort
1 position(s) available at
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Germany
Neuherberg (bei München)

EURAXESS Angebots-ID: 539046
Angebots-ID der veröffentlichenden Einrichtung: 7819_en

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