01/07/2020
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PhD Position in SECRET-ITN - Proteomics of the cancer secretome

Dieses Jobangebot ist nicht mehr aktuell


  • ORGANISATION/EINRICHTUNG
    VU University Medical Center Amsterdam
  • FORSCHUNGSBEREICH
    Biological sciences
  • KARRIERESTUFE
    First Stage Researcher (R1)
  • BEWERBUNGSFRIST
    15/08/2020 18:00 - Europe/Brussels
  • STANDORT
    Netherlands › Amsterdam
  • KONTAKTTYP
    Temporary
  • JOB STATUS
    Full-time
  • STUNDEN PRO WOCHE
    40
  • ANGEBOT BEGINN
    01/09/2020
  • EU-FORSCHUNGSRAHMENPROGRAMM
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    859962

OFFER DESCRIPTION

Proteomics investigation of the malignant functions and diagnostic potential of the cancer secretome: Focus on classically secreted proteins

Project description:

The cancer secretome harbors classically secreted (focus candidate Project 2.2) and vesicle (exosome)-based proteins (focus candidate Project 2.1) promoting invasion and proliferation. Therefore unbiased analysis using mass spectrometry-based proteomics combined with functional data mining has great potential to uncover drug targets and biomarkers for non-invasive diagnostic applications. 

Secretome and exosome proteomics of clinical material (focus colorectal cancer) will be further explored in pan-cancer cell models and clinical material. Drug target potential of selected regulatory proteins/pathways will be tested in functional experiments in vitro and the biomarker potential in clinical cohorts. 

Location: Cancer Center Amsterdam, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands

Principal Investigator: Prof Connie Jimenez (VUmc)

Collaborators IRP 2.2: Dr. Irene Bijnsdorp, Cancer Center Amsterdam, Amsterdam University Medical Center, Dr. Meike de Wit, Netherlands Cancer Institute, Amsterdam, The Netherlands (VUmc); Prof Matthias Schwab, Robert-Bosch-Krankenhaus, Germany (RBK); Prof Leonidas Alexopoulos, ProtATonce, Greece (PAO)

Mehr Information

Eligibility criteria

Eligibility

Who can apply?

Applicants shall, at the time of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and not yet have been awarded a doctoral degree.

Full-Time Equivalent Research Experience is measured from the date when a researcher obtained the degree which would formally entitle him/her to embark on a doctorate.

Mobility Rule: at the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the recruitment date*. Compulsory national service and/or short stays such as holidays are not taken into account.

Selection process

Applications are invited from candidates of excellence wishing to pursue a PhD degree in the field of cancer cell biology. Students will receive training within a pan-European academic/private sector research training network, specifically focused on breast and colorectal cancer research. Please see the project descriptions below for further information.

Project(s): Project 2.1

Required documents: a full CV, a motivation letter including a description of previous research experiences and contact details or recommendation letters of two 2 referees. Only documents in English will be accepted.

Submission: Applicants should submit the documentation to SECRET@izi.uni-stuttgart.de, writing on the subject line Project 2.2) by August 15th, 6:00 PM (CET).

For more information, see the SECRET-ITN project website: https://secret-itn.eu/jobs/

The Early Stage Researcher (ESR) will be the driving force of an Individual Research Project (IRP), to be completed within 4 years. The ESR will be hosted in  the beneficiaries' labs, and will have the opportunity to complement his/her work with at least two secondments within beneficiary or partner institutions.

Anforderungen für das Jobangebot

  • ERFORDERLICHES BILDUNGSNIVEAU
    Biological sciences: Master Degree or equivalent
  • ERFORDERLICHE SPRACHEN
    ENGLISH: Excellent

Kenntnisse/Qualifikationen

Skills and Qualifications:

· The candidate should have a Master degree in the area of biology, biomedical or biomolecular sciences.

· Experience with cancer research, proteomics experiments and bioinformatics analysis of large (OMICs) datasets is an advantage.

· We look for a candidate with inquisitive and creative mind, with a positive, flexible attitude, combined with a team spirit and good presentation and writing skills.

· 4 year duration

Besondere Anforderungen

- Master degree or equivalent in in the area of biology, biomedical or biomolecular sciences.

- Proficient English skills

Eligibility

Who can apply?

Applicants shall, at the time of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and not yet have been awarded a doctoral degree.

Full-Time Equivalent Research Experience is measured from the date when a researcher obtained the degree which would formally entitle him/her to embark on a doctorate.

Mobility Rule: at the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the recruitment date*. Compulsory national service and/or short stays such as holidays are not taken into account.

Karteninformation

Arbeitsort Orte für persönliche Beratung
Arbeitsort
1 position(s) available at
OncoProteomics Laboratory
Netherlands
Amsterdam

EURAXESS Angebots-ID: 537948

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