02/06/2020
The Human Resources Strategy for Researchers

PhD fellowship in High Resolution Mass Spectrometry applied to Cultural Heritage (M/F)

Dieses Jobangebot ist nicht mehr aktuell


  • ORGANISATION/EINRICHTUNG
    CNRS
  • FORSCHUNGSBEREICH
    ChemistryComputational chemistry
    ChemistryPhysical chemistry
  • KARRIERESTUFE
    First Stage Researcher (R1)
  • BEWERBUNGSFRIST
    23/06/2020 23:59 - Europe/Brussels
  • STANDORT
    France › BORDEAUX
  • KONTAKTTYP
    Temporary
  • JOB STATUS
    Full-time
  • STUNDEN PRO WOCHE
    35
  • ANGEBOT BEGINN
    01/09/2020

Place of employment: The Institute of Chemistry and Biology of Membrane and NanoObjects (CBMN), UMR CNR 5248 and Proteome Platform of the University of Bordeaux.
Environment: The project will benefit from the exceptional environment of the CNRS International Associated Laboratory ARCHE with The Metropolitan Museum of Art, New York, U.S.A. (Co-Directors: J. Arslanoglu, C. Tokarski, open in 2019).
Expertise of the laboratory team and platform: “Omics” developments based on high-end technologies applied to various fields (biology, chemistry, medicine, pharmaceutical science, plant science, environment, cultural heritage) from sample preparation to (bio)macromolecular identification, structural analysis, targeted/non-targeted quantitative analysis and intact protein characterization using top-down analysis. Website: https://proteome.cgfb.u-bordeaux.fr/en/proteome.
Considering Cultural Heritage: coordinator /partner of cross-disciplinary projects and European networks (JPI-JHEP LeadART, ETN TEMPERA, ETN PUSHH, IPERION HS), organization of the 1st School and associated Symposium on Advanced Mass Spectrometry Applied to Cultural Heritage involving a consortium of pioneer researchers in the field (https://hrms-heritage2019.org/; http://bss-appliedchemistry.u-bordeaux.fr/en/Bordeaux-Summer-Schools/r96...).

The analysis of Cultural Heritage samples is crucial for the understanding of artists' technique, the conservation and the preservation of artworks. The studied artworks are priceless and the sample size available for analysis is extremely low, thus requiring the development of the most efficient, informative and robust analytical methodologies.
The PhD project proposes to decipher the complexity of Cultural Heritage organic materials using unexplored developments in both chemistry and high resolution mass spectrometry to achieve structural information on the biological compounds in their environments and to map their degradation state. One of the challenges is linked to the chemical decoding of the organic molecular network. Applied to the study of artworks, this information will have a major impact on the understanding of artworks' construction, composition and degradation, and will aid in determining preservation conditions (conservation treatment and storage).
This proposed research will exploit the latest technical developments in high-resolution mass spectrometry as well as alternative fragmentation modes (ETD, UVPD) for the study of intact or transformed biomolecules found in cultural heritage material.
The major objectives of this PhD project are the development and optimization of: (i) fully-adapted and original sample preparations tailored to the study of very small sample amounts (trace analysis), to circumvent the complex inorganic/organic nature of the formulated materials of interest and (ii) top down methods to study proteins modifications, breakdowns, cross-linkings and their relationship to the surrounding matrix made of mixtures of organic and inorganic compounds. To help in this complex task, development of customized software solutions will be proposed in collaboration with bioinformatics experts (local and European collaborations).
This PhD project will address specific questions about material manufacture or origin (i.e. to gain knowledge on the formulations of the master artists or societal information) and its degradation state (i.e. effect of particular conservation treatments).
The candidate will have to interact with art conservators, historians and archaeologists from the partners' museums within an interdisciplinary research environment.
The project will require careful development of activities for public engagement as well as writing scientific articles, papers, reports or books, as appropriate.

Additional comments

Essential and Preferred Experience and Skills
- Chemistry or biochemistry background
- Demonstrated knowledge of analytical chemistry, in particular, mass spectrometry and chromatography techniques (theoretical and experimental).
- Demonstrated experience in tandem MS-based proteomics data generation and analysis is a valued plus.
- Demonstrated experience in interpretation of MS/MS data, bioinformatics analysis and statistical validation of the results is a valued plus.
- Strong or demonstrated interest in art and art preservation is a valued plus.

Other Skills
- Good communication skills in written and oral English is required.
- Integrity, motivation, organization, and good collaboration skills.
- Ability to comfortably work in a highly interdisciplinary environment with colleagues with different scientific and non-scientific backgrounds.
- Knowledge of use and conservation of proteinaceous materials in art and archaeology is a valued plus.

Elegibility:
Selection process steps:
- Pre-selection based on the applicant's CV and cover letter
- Interview (video conference or personal interview)
Criteria used for selection of the candidate: skills previously detailed

Web site for additional job details

Erforderliche Forschungserfahrung

  • FORSCHUNGSBEREICH
    ChemistryPhysical chemistry
  • JAHRE DER FORSCHUNGSERFAHRUNG
    None
  • FORSCHUNGSBEREICH
    ChemistryComputational chemistry
  • JAHRE DER FORSCHUNGSERFAHRUNG
    None

Anforderungen für das Jobangebot

  • ERFORDERLICHES BILDUNGSNIVEAU
    Chemistry: Master Degree or equivalent
  • ERFORDERLICHE SPRACHEN
    FRENCH: Basic
Arbeitsort
1 position(s) available at
INSTITUT DE CHIMIE ET DE BIOLOGIE DES MEMBRANES ET DES NANOOBJETS
France
BORDEAUX

EURAXESS Angebots-ID: 528603
Angebots-ID der veröffentlichenden Einrichtung: 15699

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