Microenvironmental Control Of Hallmarks of Cancer

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    International Giessen Graduate Centre for the Life Sciences
    Biological sciencesBiology
    First Stage Researcher (R1)
    22/07/2018 17:00 - Europe/Athens
    Germany › Giessen

Regions of low oxygen tension are common findings in malignant tumors,being associated with increased frequency of tumor invasion and metastasis, and thus critically determining the clinical behaviour and outcome of tumors. The proposed projects will aim to dissect the intersection of oxygen sensing pathways with other cellular signalling pathways, including growth factor/RTK and metabolic signalling, which are involved in cancer cell proliferation, metabolism, invasion, metastasis and self-renewal. The effect of signaling crosstalk will be further determined on the epigenetic regulation of target genes and on their posttranscriptional control. For this a wide spectrum of methods will be employed, which are regularly used in our laboratory: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, miRNA analyses, DNA methylation array analysis, chromatin immunoprecipitation, bioinformatic analysis, animal models and in vivo tumor models.

Applicants may choose between different interdisciplinary research sections: Neurosciences; Chemical Design and Analysis of Molecular Systems. A Master´s degree or equivalent is required for admission. Prospective research projects, names of supervisors and other information necessary for application can be found at:


Please submit your application using our online system before July 22, 2018. Please direct any enquiries concerning the online application procedure to the GGL office@ggl.uni-giessen.de.


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Anforderungen für das Jobangebot

    ENGLISH: Good


We are looking for enthusiastic and highly motivated biology, biochemistry or pharmacy students holding, or about to obtain, an MSc degree, diploma or equivalent, with a strong interest in tumor biology and a background in molecular or cell biology.


2 position(s) available at
International Giessen Graduate Centre

EURAXESS Angebots-ID: 279116